Binding of aminoglycoside antibiotics to acidic mucopolysaccharides.

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Binding of aminoglycoside antibiotics to acidic mucopolysaccharides.

Binding of aminoglycoside antibiotics to acidic mucopolysaccharides has been studied by means of physicochemical methods. Reactivity was affected markedly by the ionic environment , e.g. pH and ionic strength of the medium, the concentrations and the molar ratios of the constituents. The ionic character of binding was further confirmed by gel chromatography. The reduction of metachromasis by an...

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ژورنال

عنوان ژورنال: The Journal of Antibiotics

سال: 1978

ISSN: 0021-8820,1881-1469

DOI: 10.7164/antibiotics.31.150